Identification | Back Directory | [Name]
L-NIO DIHYDROCHLORIDE | [CAS]
36889-13-1 | [Synonyms]
L-NIO L-NIO, 2HCL L-NIO DIHYDROCHLORIDE L-NIO (hydrochloride) n(g)-iminoethylornithine L-N5-(1-Iminoethyl)ornithine L-N5-(1-Iminoethyl)Ornithine,HCl L-N5-(1-IMINOETHYL)-ORNITHINE 2HCL N(5)-(1-IMINOETHYL)-L-ORNITHINE HCL L-N5-(I-IMINOETHYL)ORNITHINE HYDROCHLORIDE NG-(1-IMINOETHYL)-L-ORNITHINE HYDROCHLORIDE N5-(1-IMINOETHYL)-L-ORNITHINE HYDROCHLORIDE L-N5-(1-IMINOETHYL) ORNITHINE, HYDROCHLORIDE N5-(1-IMINOETHYL)-L-ORNITHINE DIHYDROCHLORIDE L-N5-(1-IMINOETHYL)ORNITHINE, DIHYDROCHLORIDE L-N5-(1-Iminoethyl)-ornithine dihydrochloride,97% L-N5-(I-IMINOETHYL)ORNITHINE HYDROCHLORI DE POTENT IRREVERSIBLE N | [Molecular Formula]
C7H15N3O2.2ClH | [MDL Number]
MFCD00153817 | [MOL File]
36889-13-1.mol | [Molecular Weight]
246.14 |
Chemical Properties | Back Directory | [Appearance]
White Crystalline Solid | [Melting point ]
225-226°C | [storage temp. ]
-20°C | [solubility ]
Methanol (Slightly), Water (Slightly) | [form ]
Solid | [color ]
White to Off-White | [Water Solubility ]
H2O: 2mg/mL, clear (warmed) | [Stability:]
Hygroscopic |
Hazard Information | Back Directory | [Chemical Properties]
White Crystalline Solid | [Uses]
A potent and reversible inhibitor of NO synthase of adrenal glands, brain, and vascular endothelial cells | [Biological Activity]
Potent inhibitor of endothelial NO synthase (IC 50 = 500 nM). Also inhibits iNOS and nNOS. Active in vivo . | [Description]
L-NIO is a non-selective inhibitor of all NOS isoforms. The Ki values for nNOS (rat), eNOS (bovine), and iNOS (mouse) are 1.7, 3.9, and 3.9 μM, respectively. L-NIO inhibits endothelial-dependent relaxation induced by acetylcholine in rat aortic rings and hypotensive responses to acetylcholine and bradykinin. | [Definition]
ChEBI: L-NIO is a L-alpha-amino acid. |
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