| Identification | Back Directory | [Name]
METHOXY-(-)-VERAPAMIL HYDROCHLORIDE | [CAS]
36622-40-9 | [Synonyms]
(-)-D 600
(-)-Gallopamil
(-)-Methoxyverapamil
(-)-METHOXYVERAPAMIL HYDROCHLORIDE
METHOXY-(-)-VERAPAMIL HYDROCHLORIDE
(-)-VERAPAMIL, METHOXY-, HYDROCHLORIDE | [Molecular Formula]
C28H41ClN2O5 | [MDL Number]
MFCD00069306 | [MOL File]
36622-40-9.mol | [Molecular Weight]
521.09 |
| Hazard Information | Back Directory | [Uses]
(-)-Gallopamil exerts a selective modulation of the fast voltage-dependent inactivation. (-)-Gallopamil inhibits efficiently Cav1.2 constructs formed by β-subunits (promoting fast voltage-dependent inactivation). (-)-Gallopamil also accelerates the voltage-dependent phase of ICa decay (as well as the voltage-dependent decay of Ba2+ currents). (-)-Gallopamil is promising for research of antiarrhythmics[1][2]. | [References]
[1] Sokolov S, et al. On the role of Ca(2+)- and voltage-dependent inactivation in Ca(v)1.2 sensitivity for the phenylalkylamine (-)gallopamil. Circ Res. 2001 Oct 12;89(8):700-8. DOI:10.1161/hh2001.098983
[2] Sokolov S, et al. Inactivation determinant in the I-II loop of the Ca2+ channel alpha1-subunit and beta-subunit interaction affect sensitivity for the phenylalkylamine (-)gallopamil. J Physiol. 1999 Sep 1;519 Pt 2(Pt 2):315-22. DOI:10.1111/j.1469-7793.1999.0315m.x |
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