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ChemicalBook--->CAS DataBase List--->364042-47-7

364042-47-7

364042-47-7 Structure

364042-47-7 Structure
IdentificationBack Directory
[Name]

A 419259 trihydrochloride
[CAS]

364042-47-7
[Synonyms]

A419259
RK20449
RK-20449
A 419259
A-419259
RK 20449
A-419259 HCl
A 419259 trihydrochloride
7-((1r,4r)-4-(4-methylpiperazin-1-yl)cyclohexyl)-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-[trans-4-(4-methyl-1-piperazinyl)cyclohexyl]-5-(4-phenoxyphenyl)-
7-[Trans-4-(4-methyl-1-piperazinyl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine trihydrochloride
[Molecular Formula]

C29H34N6O
[MDL Number]

MFCD28155266
[MOL File]

364042-47-7.mol
[Molecular Weight]

482.62
Chemical PropertiesBack Directory
[Boiling point ]

686.4±55.0 °C(Predicted)
[density ]

1.29±0.1 g/cm3(Predicted)
[storage temp. ]

room temp
[solubility ]

H2O: soluble10mg/mL (clear solution)
[form ]

powder
[pka]

8.20±0.42(Predicted)
[color ]

white to beige
[Water Solubility ]

H2O: 10mg/mL (clear solution)
Safety DataBack Directory
[WGK Germany ]

3
Hazard InformationBack Directory
[Description]

A-419259 is an inhibitor of Src family kinases, including Src, LCK, Lyn, and Hck (IC50s = 9, <3, <3, and 11.26 nM, respectively)., It is selective for these kinases over c-Abl (IC50 = 3,000 nM) and PKC (IC50 = >33 μM). A-419259 inhibits growth of Philadelphia chromosome-positive (Ph+) K-562 and Meg-01 myeloid leukemia cells (IC50s = 0.1-0.3 and 0.1 μM, respectively), but not Ph- TF-1 and HEL cells. It induces apoptosis in K-562 cells in a concentration-dependent manner. A-419259 (300 nM) inhibits differentiation of murine embryonic stem cells while maintaining pluripotency. It reduces the total number of acute myeloid leukemia (AML) cells, as well as AML stem cells, in the bone marrow and spleen in mouse patient-derived xenograft (PDX) models of AML when administered at a dose of 30 mg/kg twice daily.
[Uses]

A 419259 Trihydrochloride is the hydrochloride form of A 419259 which is a Src kinase inhibitor and can be used in treatment of chronic myelogenous leukemia, lymphangioleiomyomatosis and tuberous sclerosis.
[storage]

Store at -20°C
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