| Identification | Back Directory | [Name]
MELPERONE | [CAS]
3575-80-2 | [Synonyms]
Buronil
FG 5111
Melperon
metylperon
Flubuperone
Melperone >
Melperone,Inhibitor,inhibit
Melperone (base and/or unspecified salts)
γ-(4-Methylpiperidino)-p-fluorobutyrophenone
4-Fluoro-γ-(4-Methylpiperidino)butyrophenone
4'-Fluoro-4-(4-Methylpiperidino)butyrophenone
1-(4-Fluorophenyl)-4-(4-methylpiperidin-1-yl)-1-butanone
1-(4-Fluorophenyl)-4-(4-methylpiperidin-1-yl)butan-1-one
1-(4-Fluorophenyl)-4-(4-Methyl-1-piperidinyl)-1-butanone
1-Butanone, 1-(4-fluorophenyl)-4-(4-methyl-1-piperidinyl)- | [EINECS(EC#)]
609-173-2 | [Molecular Formula]
C16H22FNO | [MDL Number]
MFCD00867737 | [MOL File]
3575-80-2.mol | [Molecular Weight]
263.354 |
| Chemical Properties | Back Directory | [Melting point ]
78.0 to 82.0 °C | [Boiling point ]
bp0.1 120-125° | [density ]
1.046±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 41.67 mg/mL (158.23 mM) | [form ]
powder to crystal | [pka]
9.34±0.10(Predicted) | [color ]
White to Light yellow to Light orange | [Merck ]
14,5827 |
| Hazard Information | Back Directory | [Originator]
Eunerpan,Nordmark,W. Germany,1965 | [Definition]
ChEBI: 1-(4-fluorophenyl)-4-(4-methyl-1-piperidinyl)-1-butanone is an aromatic ketone. | [Manufacturing Process]
A solution or dispersion consisting of 20.1 g (0.1 mol) of γ-chloro-pfluorobutyrophenone, 19.8 g (0.2 mol) of 4-methylpiperidine and 0.1 g of potassium iodide in 150 ml toluene is heated in a sealed glass tube for 15 hours at 100°C to 110°C. The potassium iodide and the 4-methylpiperidine hydrochloride formed in the reaction are separated by filtration and the solvent removed from the filtrate by evaporation in vacuum on a steam bath. The residue is distilled and the fraction obtained at 120°C to 125°C and at a pressure lower than 0.1 mm Hg is collected. The base is dissolved in ether and the 4-fluoro-γ-(4-methylpiperidino)-butyrophenone precipitated as the hydrochloride. The reaction product is purified by recrystallization in ethanol/ether.
Yield 22.0 g (73% of theory). MP 209°C to 211°C. | [Therapeutic Function]
Neuroleptic |
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