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ChemicalBook--->CAS DataBase List--->353229-59-1

353229-59-1

353229-59-1 Structure

353229-59-1 Structure
IdentificationBack Directory
[Name]

EthanesulfonaMide, 2,2,2-trifluoro-N-[4-(2-Methoxyphenoxy)phenyl]-N-(3-pyridinylMethyl)-, Monohydrochloride
[CAS]

353229-59-1
[Synonyms]

LY487379 HCl
LY-487379 hydrochloride,LY487379 hydrochloride
N-(4-(2-Methoxyphenoxy)phenyl)-N-(2,2,2- trifluoroethylsulfonyl)pyrid-3-ylmethylamine hydrochloride
2,2,2-trifluoro-N-[4-(2-methoxyphenoxy)phenyl]-N-(pyridin-3-ylmethyl)ethanesulfonamide:hydrochloride
EthanesulfonaMide, 2,2,2-trifluoro-N-[4-(2-Methoxyphenoxy)phenyl]-N-(3-pyridinylMethyl)-, Monohydrochloride
[Molecular Formula]

C21H20ClF3N2O4S
[MDL Number]

MFCD11519970
[MOL File]

353229-59-1.mol
[Molecular Weight]

488.91
Chemical PropertiesBack Directory
[storage temp. ]

2-8°C
[solubility ]

DMSO: >20mg/mL
[form ]

powder
[color ]

off-white
Safety DataBack Directory
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

LY 487379 Hydrochloride is a group II mGlu receptors activator with anti-hyperthermic effects. Allosteric potentiators of metabotropic glutamate receptor 2 (mGlu2).
[in vivo]

LY487379 hydrochloride (intraperitoneal injection; 30 mg/kg; injected 30 min before the test) requires significantly fewer trials to criterion during the ED phase of the ASST in attentional set-shifting task in male Sprague-Dawley rats. But there has no significant drug effect during any other discrimination stage[1].LY487379 hydrochloride (intraperitoneal injection; 10-30 mg/kg) induces an increase in microdialysate norepinephrine levels; the dose-effect resembled a bell-shape relationship increased. And it dose-dependently increases extracellular serotonin levels in the medial prefrontal cortex in male Sprague-Dawley rats[1].

[storage]

Store at -20°C
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