| Identification | Back Directory | [Name]
Necrostatin-7 (Nec-7) | [CAS]
351062-08-3 | [Synonyms]
Nec-7
Necrostatin-7
Necrostatin-7 (Nec-7)
Necrostatin-7 >=98% (HPLC), powder
5-[[3-(4-Fluorophenyl)-1H-pyrazol-4-yl]methylene]-2-imino-3-(2-thiazolyl)-4-thiazolidinone
4-Thiazolidinone, 5-[[3-(4-fluorophenyl)-1H-pyrazol-4-yl]methylene]-2-imino-3-(2-thiazolyl)-
(5Z)-5-[[5-(4-fluorophenyl)-1H-pyrazol-4-yl]methylidene]-2-imino-3-(1,3-thiazol-2-yl)-1,3-thiazolidin-4-one | [Molecular Formula]
C16H10FN5OS2 | [MDL Number]
MFCD02334728 | [MOL File]
351062-08-3.mol | [Molecular Weight]
371.41 |
| Chemical Properties | Back Directory | [Boiling point ]
613.4±65.0 °C(Predicted) | [density ]
1.63±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: >10mg/mL (with warming) | [form ]
powder | [pka]
11.56±0.50(Predicted) | [color ]
yellow to tan |
| Hazard Information | Back Directory | [Biological Activity]
Necrostatin-7 (Nec-7) is a potent inhibitor of necroptosisa regulated caspase-independent necrotic cell death pathwaydistinct from apoptosis. Nec-7 has a different profile from the other necrostatins as it does not inhibit RIP1 kinasesuggesting the possibility th at it may target an additional as yet unknown regulatory molecule in the pathway. | [storage]
+4°C |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|