Identification | Back Directory | [Name]
KRIBB11 | [CAS]
342639-96-7 | [Synonyms]
KRIBB11 CS-2403 KRIBB 11;KRIBB-11 N2-1H-Indazol-5-yl-N6-methyl-3-nitro-2,6-pyridinediamine 2,6-Pyridinediamine, N2-1H-indazol-5-yl-N6-methyl-3-nitro- | [Molecular Formula]
C13H12N6O2 | [MDL Number]
MFCD30182306 | [MOL File]
342639-96-7.mol | [Molecular Weight]
284.27 |
Chemical Properties | Back Directory | [Boiling point ]
534.9±50.0 °C(Predicted) | [density ]
1.531±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO:27.0(Max Conc. mg/mL);94.98(Max Conc. mM) | [form ]
powder | [pka]
13.59±0.40(Predicted) | [color ]
yellow to orange |
Hazard Information | Back Directory | [Uses]
KRIBB 11 is a heat shock factor (HSF) inhibitor that induces apoptosis in cancer cells. KRIBB 11 exhibits anticancer properties. | [Biological Activity]
KRIBB11 is an inhibitor of the transcription factor He at Shock Factor 1 (HSF1) with an IC50 value of 1.2 μM. KRIBB11 blocks induction of HSF1 downstream target proteins such as HSP27 and HSP70 by impairing the recruitment of Positive Transcription Elongation Factor b (P-TEFb) to the HSF1 transcriptional complexpreventing HSF1-mediated gene expression KRIBB11 inhibits tumor growth in vivo and acts synergistically to increase apoptosis in cancer cells treated with the HSP90 inhibitors Geldanamycin and 17-AAG.''KRIBB11 is capable of preventing the proliferation of cancer cells. It has the ability to stimulate apoptosis and can arrest the cell cycle at G2/M phase. | [storage]
Store at -20°C |
|
|