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ChemicalBook--->CAS DataBase List--->335166-00-2

335166-00-2

335166-00-2 Structure

335166-00-2 Structure
IdentificationBack Directory
[Name]

Bax Channel Blocker II, iMAC2 - CAS 335166-00-2 - Calbiochem
[CAS]

335166-00-2
[Synonyms]

Bax Channel Blocker II, iMAC2 - CAS 335166-00-2 - Calbiochem
[Molecular Formula]

C19H21Br2ClFN3
[MDL Number]

MFCD20926332
[MOL File]

335166-00-2.mol
[Molecular Weight]

505.65
Chemical PropertiesBack Directory
[storage temp. ]

2-8°C
[solubility ]

Soluble to 5 mM in DMSO
[form ]

solid
[color ]

off-white
Hazard InformationBack Directory
[Uses]

iMAC2 is a mitochondrial apoptosis-induced channel (MAC) inhibitor.
[General Description]

A MAC (Mitochondrial Apoptosis-induced Channel) inhibitor iMAC1 (Cat. No. 196805) structural analog that is reported to be less potent than iMAC1 in blocking Bid-induced cytochrome c release in cell-free mitochondria preparations (40% vs. 77% inhibition with 5 μM respective inhibitor), but more effective than iMAC1 in inhibiting STS- (Cat. No. 569396 & 569397) induced cytochrome c release in intact FL5.12 cells (Complete vs ~35% inhibition with 5 μM respective inhibitor), presumably due to an enhanced permeability. iMAC2 is also shown to be a superior blocker of MAC-mediated current flow in reconstituted mitochondrial outer membrane patches from apoptotic FL5.12 cells (IC50 = 28 vs 300 nM in the case of iMAC2 and iMAC1, respectively) and protect FL5.12 from STS-induced apoptosis (IC50 = 2.5 μM).
[storage]

Desiccate at RT
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