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ChemicalBook--->CAS DataBase List--->333742-48-6

333742-48-6

333742-48-6 Structure

333742-48-6 Structure
IdentificationBack Directory
[Name]

AZD-8309 (AZD8309)
[CAS]

333742-48-6
[Synonyms]

AZD-8309
AZD-8309 (AZD8309)
[Molecular Formula]

C15H14F2N4O2S2
[MOL File]

333742-48-6.mol
[Molecular Weight]

384.42
Chemical PropertiesBack Directory
[density ]

1.56±0.1 g/cm3(Predicted)
[form ]

Solid
[pka]

6.85±0.20(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Description]

AZD8309 is an oral CXCR2 antagonist.
[Uses]

AZD8309 is an orally active antagonist of CXCR2. AZD8309 has the ability to regulate the transmigration of neutrophils. AZD8309 can be used in the study of inflammatory diseases[1].
[in vivo]

AZD8309 (50 mg/kg; p.o.; twice daily) reduces neutrophil migration and pancreatic protease activation in experimental pancreatitis in mice[1].

Animal Model:Male C57BL6 mice (25-30 g) with experimental pancreatitis[1]
Dosage:50 mg/kg
Administration:Oral gavage; twice daily starting 3 h prior to pancreatitis induction
Result:Significantly reduced MPO in the pancreas and lungs (8 h & 24 h) and reduced intrapancreatic trypsin and elastase activity (8 h) in caerulein-pancreatitis.
Reduced serum cytokine levels as well as histopathological damage.
[IC 50]

CXCR2: 4 nM (IC50)
[References]

[1] Malla SR, et al. Effect of oral administration of AZD8309, a CXCR2 antagonist, on the severity of experimental pancreatitis. Pancreatology. 2016 Sep-Oct;16(5):761-9. DOI:10.1016/j.pan.2016.07.005
[2] Walters I, Austin C, Austin R, et al. Evaluation of a series of bicyclic CXCR2 antagonists. Bioorg Med Chem Lett. 2008;18(2):798-803. DOI:10.1016/j.bmcl.2007.11.039
Spectrum DetailBack Directory
[Spectrum Detail]

AZD-8309 (AZD8309)(333742-48-6)1HNMR
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