| Identification | Back Directory | [Name]
4,4-dimethyl-1-(3-nitrophenyl)-2-(1H-1,2,4-triazol-1-yl)-1-penten-3-one | [CAS]
331949-35-0 | [Synonyms]
Nexinhib20,Nexinhib-20
4,4-dimethyl-1-(3-nitrophenyl)-2-(1H-1,2,4-triazol-1-yl)-1-penten-3-one
1-Penten-3-one, 4,4-dimethyl-1-(3-nitrophenyl)-2-(1H-1,2,4-triazol-1-yl)- | [Molecular Formula]
C15H16N4O3 | [MDL Number]
MFCD00219515 | [MOL File]
331949-35-0.mol | [Molecular Weight]
300.31 |
| Chemical Properties | Back Directory | [Boiling point ]
508.2±60.0 °C(Predicted) | [density ]
1.23±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 30 mg/ml; Ethanol: 15 mg/ml | [form ]
A crystalline solid | [pka]
1.50±0.12(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
Nexinhib 20 is an inhibitor of Rab27a-JFC1 interaction, it inhibits the neutrophil exocytosis and inflammation | [Biological Activity]
Nexinhib20 (neutrophil exocytosis inhibitor 20) is a potent inhibitor of the interaction between the small GTPase Rab27a and its effector JFC1 (synaptotagmin-like protein1). Nexinhib20 inhibits exocytosis of azurophilic granules in human neutrophils without affecting other important innate immune responses including phagocytosis and neutrophil extracellular trap production.''Nexinhib20 prevents the expression of cytochrome b558 in the plasma membrane. It modulates vesicular trafficking and neutrophil activities. Nexinhib20 reduces the systemic inflammationmediated by neutrophils. | [in vivo]
Nexinhib20 (100 mM; 10 μL; intraperitoneal injection; single dose) has a protective effect in a mouse model of myocardial I/R injury[2]. | Animal Model: | C57BL/6J mice with ischemia-reperfusion injury[2] | | Dosage: | 100 mM; 10 μL | | Administration: | Intraperitoneal injection (i.p.); single dose | | Result: | Significantly decreased infarct size (white area in the TTC-phthalo-blue-staining) after myocardial I/R injury.
Limited neutrophil recruitment to the coronary artery.
Improved left ventricular function.
|
| [storage]
Store at +4°C |
|
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
| Company Name: |
R&D Systems, Inc
|
| Tel: |
18003437475 18003437475 |
| Website: |
www.rndsystems.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|