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ChemicalBook--->CAS DataBase List--->331862-41-0

331862-41-0

  • <center id="ov7l4"><tbody id="ov7l4"></tbody></center>
      331862-41-0 Structure

      331862-41-0 Structure
      IdentificationBack Directory
      [Name]

      IMR-1A
      [CAS]

      331862-41-0
      [Synonyms]

      IMR-1A
      IMR-1A, >98%
      IMR1A;IMR 1A;IMR-1A
      Acetic acid, 2-[2-methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]-
      [Molecular Formula]

      C13H11NO5S2
      [MDL Number]

      MFCD04083080
      [MOL File]

      331862-41-0.mol
      [Molecular Weight]

      325.36
      Chemical PropertiesBack Directory
      [density ]

      1.55±0.1 g/cm3(Predicted)
      [storage temp. ]

      Inert atmosphere,2-8°C
      [solubility ]

      DMSO:4.0(Max Conc. mg/mL);12.29(Max Conc. mM)
      Water:1.0(Max Conc. mg/mL);3.07(Max Conc. mM)
      [form ]

      Solid
      [pka]

      3.10±0.10(Predicted)
      [color ]

      Light yellow to yellow
      Safety DataBack Directory
      [Symbol(GHS) ]


      GHS07
      [Signal word ]

      Warning
      [Hazard statements ]

      H302-H315-H319-H335
      [Precautionary statements ]

      P261-P305+P351+P338
      Spectrum DetailBack Directory
      [Spectrum Detail]

      IMR-1A(331862-41-0)1HNMR
      Hazard InformationBack Directory
      [Biological Activity]

      IMR-1A is a potent inhibitor of Notch with IC50 of 0.5 μM and Kd of 2.9 μM. It has antitumor activity.
      [in vivo]

      IMR-1A (2 mg/kg (iv) and 100 mg/kg (ip)) exhibits low systematic plasma clearance (CL = 7 mL/min/kg) with terminal elimination half-life (T1/ 2) of 2.22 h following a single iv administration. The normal liver blood flow in mice is 90 mL/min/kg and the Vss (volume of distribution) is ~4-fold. Plasma concentrations is quantifiable up to 24 h with Tmax of 0.50 h after ip administration.

      < td class="col1 fwb"> Administration:
      Animal Model: Male C57 BL/6 mice
      Dosage: 2 mg/kg (iv) and 100 mg/kg (ip)
      Iv and ip
      Result: Exhibited low systematic plasma clearance (CL = 7 mL/min/kg) with terminal elimination half-life (T1/2) of 2.22 h following a single iv administration and plasma concentrations is quantifiable up to 24 h with Tmax of 0.50 h after ip administration.
      [target]

      < /table>
      TargetValue
      Notch
      (Cell-free assay)
      0.5 μM
      Notch
      (Cell-free assay)
      2.9 μM(Kd)
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