| Identification | Back Directory | [Name]
N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide | [CAS]
329196-48-7 | [Synonyms]
SANT-2
Hh Signaling Antagonist XIV, SANT-2
Hh Signaling Antagonist XIV, SANT-2 - CAS 329196-48-7 - Calbiochem
N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide
Benzamide, N-[3-(1H-benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxy- | [Molecular Formula]
C26H26ClN3O4 | [MOL File]
329196-48-7.mol | [Molecular Weight]
479.96 |
| Chemical Properties | Back Directory | [Melting point ]
210-211℃ | [density ]
1.287±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: soluble20mg/mL, clear | [form ]
White powder | [pka]
10.95±0.10(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
SANT-2 is an inhibitor of Smo (Hedgehog signaling pathway) and SAG. | [General Description]
A nanomolar Smoothened (smo) antagonist that exhibits 2.3- and 6-fold weaker biological activity than SANT-1 (Cat. No. 559303), respectively, in antagonizing ShhNp- and SAG-stimulated hedgehog pathway activation in HEK 293-based (Shh-LIGHT2) reporter assays. Competitive binding studies show full replacement of Smo-bound cyclopamine (Cat. No. 239803) by SANT-1 and SANT-2 (Ki = 2.4 and 8.4 nM, respectively), while SANT-1 and SANT-2 are shown to compete against Smo-bound SAG-1.3 (Cat. Nos. 566660 & 566661) in an allosteric manner and that only SANT-2, but not SANT-1, is able to completely compete off bound SAG-1.3 (100% vs. 40% replacement by the respective compound at 10 μM). | [Biochem/physiol Actions]
SANT-2 is a potent sonic hedgehog pathway (shh) antagonist that directly inhibits by binding to the smoothened receptor. |
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