| Identification | Back Directory | [Name]
GLYCOFUROL | [CAS]
31692-85-0 | [Synonyms]
THFP
GLYCOFUROL
TETRAGLYCO
Glycofural
TETRAGLYCOL
Glycofurol75
Glycofurolum 75
GLYCOFUROL-SPECIAL
GLYCOFUROL TETRAGLYCOL
Tetraglycol ( Glycofurol)
2-(oxolan-2-ylmethoxy)ethanol
TetrahydrofurfurylAlcoholPEGether
TETRAHYDROFURFURYL POLYETHYLENE GLYCOL 200
Tetrahydrofurfuryl polyethylene glycol ether
POLY(ETHYLENE GLYCOL) TETRAHYDROFURFURYL ETHER
tetrahydrofurfurylalkoholpolyaethylenglycolaether
Glycols,polyethylene,mono(tetrahydrofurfuryl)ether
TETRAHYDROFURFURYL ALCOHOL POLYETHYLENEGLYCOL ETHER
Ethylene oxide homopolymer 2-tetrahydrofuranylmethyl ether
Glycofurol, Tetrahydrofurfuryl alcohol polyethyleneglycol ether
alpha-((tetrahydro-2-furanyl)methyl)-omega-hydroxy-poly(oxy-2-ethanediyl)
mixture of diethylene and triethylene glycol mono-tetrahydrofurfuryl ether
Tetraglycol,Glycofurol, Tetrahydrofurfuryl alcohol polyethyleneglycol ether
2-ethanediyl),alpha-[(tetrahydro-2-furanyl)methyl]-omega-hydroxy-Poly(oxy-1
alpha-((Tetrahydro-2-furanyl)methyl)-omega-hydroxy-poly(oxy-1,2-E- thanediyl)
Poly(oxy-1,2-ethanediyl), .alpha.-(tetrahydro-2-furanyl)methyl-.omega.-hydroxy-
Tetrahydrofurfuryl polyethylene glycol 200, Mixture of diethylene and triethylene glycol mono-tetrahydrofurfuryl ether | [EINECS(EC#)]
203-989-9 | [Molecular Formula]
C11H21O5R | [MDL Number]
MFCD00801146 | [MOL File]
31692-85-0.mol | [Molecular Weight]
233.28 |
| Chemical Properties | Back Directory | [Appearance]
liquid | [Melting point ]
≤ -100 °C | [Boiling point ]
100-145 °C0.4 mm Hg
| [density ]
1.09 g/mL at 25 °C(lit.)
| [vapor pressure ]
4.97-37.4Pa at 20-50℃ | [refractive index ]
n20/D 1.462(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
Store below +30°C. | [solubility ]
Chloroform (Sparingly), Methanol (Slightly, Sonicated) | [form ]
Oil | [color ]
Colourless | [Stability:]
Stable. Combustible. Incompatible with strong oxidizing agents. | [Water Solubility ]
water: soluble 3420g/L | [α-end]
tetrahydrofurfuryl ether | [Ω-end]
hydroxyl | [LogP]
-1.21--0.38 |
| Hazard Information | Back Directory | [Chemical Properties]
liquid | [Uses]
Glycofurol is used as a carrier device for drug delivery. | [Production Methods]
Glycofurol is prepared by the reaction of tetrahydrofurfuryl alcohol
with ethylene oxide (followed by a special purification process in
the case of Glycofurol 75). | [Pharmaceutical Applications]
Glycofurol is used as a solvent in parenteral products for
intravenous or intramuscular injection in concentrations up to
50% v/v. It has also been investigated, mainly in animal studies,
for use as a penetration enhancer and solvent in topical and
intranasal formulations. Glycofurol has also been used at 20%
v/v concentration in a rectal formulation. | [Biological Activity]
Liquid glycofurol can readily transform into gel systems with excellent elasticity due to whichit can be used as a medium to dissolve water-insoluble drugs. | [Safety]
Glycofurol is mainly used as a solvent in parenteral pharmaceutical
formulations and is generally regarded as a relatively nontoxic and
nonirritant material at the levels used as a pharmaceutical excipient.
Glycofurol can be irritant when used undiluted; its tolerability is
approximately the same as propylene glycol.
Glycofurol may have an effect on liver function and may have a
low potential for interaction with hepatoxins or those materials
undergong extensive hepatic metabolism.
LD50 (mouse, IV): 3.5 mL/kg | [storage]
Stable if stored under nitrogen in a well-closed container protected
from light, in a cool, dry place. | [Incompatibilities]
Incompatible with oxidizing agents. | [Regulatory Status]
Included in parenteral medicines licensed in Europe. |
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