| Identification | Back Directory | [Name]
MLS1547 | [CAS]
315698-36-3 | [Synonyms]
MLS1547
MLS000051547
MLS1547 >=98% (HPLC)
5-Chloro-7-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-8-quinolinol
8-Quinolinol, 5-chloro-7-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-
Inhibitor,inhibit,biased,β-arrestin,MLS1547,Dopamine Receptor,protein,signaling,recruitment | [Molecular Formula]
C19H19ClN4O | [MDL Number]
MFCD02330713 | [MOL File]
315698-36-3.mol | [Molecular Weight]
354.83 |
| Chemical Properties | Back Directory | [Boiling point ]
555.8±50.0 °C(Predicted) | [density ]
1.354±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 20 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 10 mg/ml; Ethanol: 5 mg/ml | [form ]
A crystalline solid | [pka]
4.08±0.30(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
MLS 1547 is a dopamine D2 receptor partial agonist which may be used in the preparation of or combination with antipsychotic drugs. | [Biological Activity]
MLS1547 is a highly efficacious D2 dopamine receptor (D2R) G protein-biased agonist th at does not recruit β-arrestinand is an antagonist of dopamine-stimulated β-arrestin recruitment to the D2 receptor. MLS-1547 is the first D2 receptor agonist with close to full efficacy for G protein signaling (EC50 = 370 nM)but no ability to recruit β-arrestin. | [IC 50]
D2 Receptor | [storage]
Store at +4°C |
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