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ChemicalBook--->CAS DataBase List--->312281-74-6

312281-74-6

312281-74-6 Structure

312281-74-6 Structure
IdentificationBack Directory
[Name]

N-(1-benzylpiperidin-4-yl)-2,4-dichlorobenzamide
[CAS]

312281-74-6
[Synonyms]

BPDBA
N-(1-benzylpiperidin-4-yl)-2,4-dichlorobenzamide
Benzamide, 2,4-dichloro-N-[1-(phenylmethyl)-4-piperidinyl]-
[Molecular Formula]

C19H20Cl2N2O
[MDL Number]

MFCD00247356
[MOL File]

312281-74-6.mol
[Molecular Weight]

363.28
Chemical PropertiesBack Directory
[form ]

Solid
[color ]

White to off-white
Hazard InformationBack Directory
[Description]

BPDBA is a noncompetitive inhibitor of the betaine/GABA transporter 1 (BGT1).
[Uses]

BPDBA is a selective and noncompetitive betaine/GABA transporter (BGT-1) inhibitor with IC50s of 20 μM and 35 μM against human BGT-1 and mouse GAT2, respectively[1].
[in vivo]

BPDBA is predicted to have excellent oral absorption and blood brain barrier penetration properties[1].

[References]

[1] Kragholm B, et al. Discovery of a subtype selective inhibitor of the human betaine/GABA transporter 1 (BGT-1) with a non-competitive pharmacological profile. Biochem Pharmacol. 2013 Aug 15;86(4):521-8. DOI:10.1016/j.bcp.2013.06.007
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