| Identification | Back Directory | [Name]
2-(1H-benzimidazol-2-ylsulfanyl)-N-(5-chloropyridin-2-yl)acetamide | [CAS]
311787-85-6 | [Synonyms]
dCeMM3
Acetamide, 2-(1H-benzimidazol-2-ylthio)-N-(5-chloro-2-pyridinyl)-
2-(1H-benzimidazol-2-ylsulfanyl)-N-(5-chloropyridin-2-yl)acetamide
2-((1H-Benzo[d]imidazol-2-yl)thio)-N-(5-chloropyridin-2-yl)acetamide
degradation,dCeMM 3,dCeMM3?,Inhibitor,inhibit,CDK,CDK12,Cyclin dependent kinase,glue degrader,dCeMM-3,cyclin K,CRL4B ligase,ubiquitination,dCeMM3 | [Molecular Formula]
C14H11ClN4OS | [MDL Number]
MFCD01304495 | [MOL File]
311787-85-6.mol | [Molecular Weight]
318.78 |
| Hazard Information | Back Directory | [Uses]
dCeMM3 (Compound 3) is a molecular glue degrader. dCeMM3 induces ubiquitination and degradation of cyclin K by prompting an interaction of CDK12-cyclin K with a CRL4B ligase complex[1]. | [References]
[1] Mayor-Ruiz C, et al. Rational discovery of molecular glue degraders via scalable chemical profiling [published correction appears in Nat Chem Biol. 2021 Mar;17(3):361]. Nat Chem Biol. 2020;16(11):1199-1207. DOI:10.1038/s41589-020-0594-x |
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