| Identification | Back Directory | [Name]
2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE | [CAS]
299442-43-6 | [Synonyms]
NKY80
AKOS B003518
VITAS-BB TBB000019
SALOR-INT L203769-1EA
Adenylyl Cyclase Type V Inhibitor, NKY80
2-AMINO-7-(FURANYL)-7,8-DIHYDRO-5(6H)-QUINAZOLINONE
2-amino-7-(2-furyl)-7,8-dihydroquinazolin-5(6H)-one
2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE
2-Amino-7-(2-furanyl)-7,8-dihydro-5(6H)-quinazolinone
5(6H)-Quinazolinone, 2-amino-7-(2-furanyl)-7,8-dihydro-
Adenylyl Cyclase Type V Inhibitor, NKY80 - CAS 299442-43-6 - Calbiochem | [Molecular Formula]
C12H11N3O2 | [MDL Number]
MFCD02026323 | [MOL File]
299442-43-6.mol | [Molecular Weight]
229.23 |
| Chemical Properties | Back Directory | [Boiling point ]
464.9±47.0 °C(Predicted) | [density ]
1.360±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
Soluble in DMSO or methanol | [form ]
powder | [pka]
1.85±0.40(Predicted) | [color ]
off-white to light brown | [Sensitive ]
Light Sensitive | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| Hazard Information | Back Directory | [Description]
NKY-80 (299442-43-6) is a potent and selective adenylyl cyclase inhibitor. Selective for AC5 and over AC3 and AC2 (IC50 = 8.3 μM, 132 μM and 1.7 mM respectively).1,2 More recently shown to indiscriminately inhibit AC6.3 NKY-80 is an extremely useful tool for probing the involvement of adenylyl cyclases in cellular signaling.4 | [Uses]
NKY 80 is an inhibitor of adenylyl cyclase (AC) and displays a greater affinity for AC5 over AC3 and AC2. Adenyl cyclase inhibitors can be easily modified by tumor targeting structures. | [General Description]
A cell-permeable quinazolinone containing a non-nucleoside compound that acts as a potent, selective inhibitor of adenylyl cyclase (AC) type V isoform (IC50 = 8.3 μM, 132 μM and 1.7 mM for type V, III and II, respectively) in the presence of Gsα GTPγS-Forskolin. Displays ~210-fold greater selectivity for type V over the type II isoform. The inhibition is non-competitive with respect to ATP and Forskolin. Regulates the AC catalytic activity in heart and lung tissues. | [Biochem/physiol Actions]
Cell permeable: yes | [storage]
Store at +4°C | [References]
1) Onda?et al. (2001),?Type-specific regulation of adenylyl cyclase. Selective pharmacological stimulation and inhibition of adenylyl cyclase isoforms; J. Biol. Chem.,?276?47785
2) Pierre?et al. (2009),?Capturing adenylyl cyclases as potential drug targets; Nat. Rev. Drug Discov.,?8?321
3) Brand?et al. (2013),?Isoform selectivity of adenylyl cyclase inhibitor: characterization of known and novel compounds; J. Pharmacol. Exp. Therap.,?347?265
4) Oritz-Capisano?et al. (2007),?Adenylyl cyclase isoform V mediates renin release from juxtaglomerular cells; Hypertension,?49?618 |
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