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ChemicalBook--->CAS DataBase List--->2982583-44-6

2982583-44-6

2982583-44-6 Structure

2982583-44-6 Structure
IdentificationBack Directory
[Name]

EGFR-IN-101
[CAS]

2982583-44-6
[Synonyms]

EGFR-IN-101
[Molecular Formula]

C35H47N9O2
[MOL File]

2982583-44-6.mol
[Molecular Weight]

625.81
Chemical PropertiesBack Directory
[Boiling point ]

823.8±75.0 °C(predicted)
[density ]

1.27±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka]

14.68±0.10(predicted)
Hazard InformationBack Directory
[Uses]

EGFR-IN-101 (I-10) is a 2-phenylamino pyrimidine derivative. EGFR-IN-101 is a EGFR inhibitor. The IC50 values for EGFRL858R/T790M/C797S and Ba/F3-EGFRL858R/T790M/C797S are 33.26 and 106.4 nM, respectively. EGFR-IN-101 can be used IN the study of non-small cell lung cancer (NSCLC)[1].
[References]

[1] Tang C, et al. Design, synthesis and biological evaluation of 2-phenylaminopyrimidine derivatives as EGFR inhibitors. Bioorg Med Chem Lett. 2024 Feb 6;101:129648. DOI:10.1016/j.bmcl.2024.129648
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