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ChemicalBook--->CAS DataBase List--->297162-49-3

297162-49-3

297162-49-3 Structure

297162-49-3 Structure
IdentificationBack Directory
[Name]

Azido-PEG6-CH2CO2t-butyl ester
[CAS]

297162-49-3
[Synonyms]

N3-PEG6-CH2COOtBu
Azido-PEG6-C1-Boc
Azido-PEG6-CH2COOtBu
AZIDO-PEG6-CH2CO2TBU
Azido-PEG6-CH2COOH t-Bu Ester
Azido-PEG6-CH2CO2t-butyl ester
[Molecular Formula]

C18H35N3O8
[MDL Number]

MFCD27977491
[MOL File]

297162-49-3.mol
[Molecular Weight]

421.49
Hazard InformationBack Directory
[Description]

Azido-PEG6-CH2CO2-t-Bu contain an azide group and a t-butyl ester. PEG spacer increases reagent's solubility in aqueous media. The azide (N3) group can react with alkyne, BCN, DBCO via Click Chemistry. The t-butyl protected carboxyl group can be deprotected under acidic condition.
[Uses]

Azido-PEG6-C1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG6-C1-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
[IC 50]

PEGs
[References]

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
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