| Identification | Back Directory | [Name]
10,11-DIHYDRO-10-HYDROXYCARBAZEPINE | [CAS]
29331-92-8 | [Synonyms]
GP 47779
BIA 2-005
GP 47779-d3
BIA 2-005-d3
Licarbazepine
Hydroxycarbamazepine
10,11-Dihydro-10-hydroxy
LICARBAZEPINE SEE 16178912
10-Hydroxy-10,11-dihydrocarbamezepine
10,11-Dihydro-10-hydroxycarbazepine-d3
10-Hydroxy-10,11-dihydrocarbamezepine-d3
10,11-Dihydro-10-Hydroxycarbamazepine solution
5-Carbamoyl-10,11-dihydro-5H-dibenzo[b,f]azepine-10-ol
6-hydroxy-5,6-dihydrobenzo[b][1]benzazepine-11-carboxamide
10,11-Dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide
10-hydroxy-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxaMide
5H-Dibenz[b,f]azepine-5-carboxaMide,10,11-dihydro-10-hydroxy-
10,11-Dihydro-10-hydroxy-5H-dibenz(Z)[b,f]azepin-5-carboxamide
10,11-Dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide-d3
(±)-10-Hydroxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxaMide | [Molecular Formula]
C15H14N2O2 | [MDL Number]
MFCD00871817 | [MOL File]
29331-92-8.mol | [Molecular Weight]
254.28 |
| Chemical Properties | Back Directory | [Appearance]
White Solid | [Melting point ]
186-189°C | [Boiling point ]
431.3±55.0 °C(Predicted) | [density ]
1.336 | [Fp ]
2℃ | [storage temp. ]
Store at RT | [solubility ]
Soluble to 100 mM in DMSO and to 50 mM in ethanol | [form ]
neat | [pka]
13.75±0.20(Predicted) | [color ]
White to off-white | [BRN ]
1540211 | [InChIKey]
BMPDWHIDQYTSHX-UHFFFAOYSA-N | [CAS DataBase Reference]
29331-92-8 |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
A labelled metabolite of Oxcarbazepine | [Uses]
A metabolite of Oxcarbazepine | [Definition]
ChEBI: A dibenzoazepine that is 5H-dibenzo[b,f]azepine, reduced across the C-10,11 positions and carrying a carbamoyl substituent at the azepine nitrogen and a hydroxy function at C-10. A voltage-gated sodium channel b
ocker with anticonvulsant and mood-stabilizing effects, it is related to oxcarbazepine and is an active metabolite of oxcarbazepine. | [Uses]
?10,11-dihydro-10-hydroxy Carbamazepinee is the active metabolite of oxcarbazepine . Oxcarbazepine is rapidly and almost completely converted to 10,11-dihydro-10-hydroxycarbamazepine, which then demonstrates anticonvulsant efficacy by modulating several ion channels and receptors. ?10,11-dihydro-10-hydroxy Carbamazepine is reported to inhibit both voltage-gated Na+ and Ca2+ channels, to potentiate voltage-gated K+ channels, to antagonize adenosine A1 receptors, to increase dopaminergic transmission, and to inhibit glutamate release. | [in vivo]
Eslicarbazepine acetate (ESL) is an oral pro-drug that is rapidly and extensively metabolized by the liver via a hydrolytic first-pass metabolism into S-Licarbazepine, the biologically active drug. The plasma level of the prodrug remains below quantification[1].
ESL is a potent antiepileptic agent with a spectrum of action essentially limited to partial-onset and generalized tonic-clonic seizures. Its main mechanism of action is by blocking the voltage-gated sodium channel. ESL works by blocking the voltage-gated sodium channel, which play an essential role in the generation and propagation of the epileptic discharge. ESL is well absorbed after oral administration with a bio-availability about 16% higher than that observed after an equivalent dose of Oxcarbazepine (OXC)[1]. | [storage]
Store at RT |
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