| Chemical Properties | Back Directory | [Boiling point ]
632.5±55.0 °C(predicted) | [density ]
1.362±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
-4.45±0.20(predicted) | [color ]
White to light brown |
| Hazard Information | Back Directory | [Uses]
GPX4-IN-5 (Compound C18) is a GPX4 covalent inhibitor with an IC50 value of 0.12 μM. GPX4-IN-5 (Compound C18) can induce ferroptosis for the research of triple-negative breast cancer (TNBC) [1]. | [References]
[1] Chen T, et al. Discovery of Novel Potent Covalent Glutathione Peroxidase 4 Inhibitors as Highly Selective Ferroptosis Inducers for the Treatment of Triple-Negative Breast Cancer. J Med Chem. 2023 Jul 27;66(14):10036-10059. DOI:10.1021/acs.jmedchem.3c00967 |
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