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ChemicalBook--->CAS DataBase List--->292170-13-9

292170-13-9

292170-13-9 Structure

292170-13-9 Structure
IdentificationBack Directory
[Name]

OM-137
[CAS]

292170-13-9
[Synonyms]

OM-137
OM137 >=95% (NMR)
2-Amino-N′-(4-hydroxy-3-methoxybenzylidene)-4-methyl-1,3-thiazole-5-carbohydrazide
5-Thiazolecarboxylic acid, 2-amino-4-methyl-, 2-[(4-hydroxy-3-methoxyphenyl)methylene]hydrazide
2-amino-N'-[(1E)-(4-hydroxy-3-methoxyphenyl)methylidene]-4-methyl-1,3-thiazole-5-carbohydrazide
[Molecular Formula]

C13H14N4O3S
[MDL Number]

MFCD02086738
[MOL File]

292170-13-9.mol
[Molecular Weight]

306.34
Chemical PropertiesBack Directory
[density ]

1.46±0.1 g/cm3(Predicted)
[storage temp. ]

room temp
[solubility ]

DMSO: >10mg/mL
[form ]

powder
[pka]

8.65±0.35(Predicted)
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
[Hazard Codes ]

Xn
[Risk Statements ]

22-36/37/38
[Safety Statements ]

26
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

OM137 is an aurora kinase inhibitor, with an IC50 of 21.7 μM (Aurora A kinase) and 2.4 μM (Aurora B kinase). OM137 also inhibits Cdk1/cyclinB and Cdk5/p25 with an approximate IC50 of 20 μM. OM137 reduces spindle checkpoint-signaling proteins (Mad2 and BubR1) at the kinetochores of chromosomes[1].
[Definition]

ChEBI: 2-amino-N'-[(3-methoxy-4-oxo-1-cyclohexa-2,5-dienylidene)methyl]-4-methyl-5-thiazolecarbohydrazide is a member of thiazoles and an aromatic amide.
[References]

[1] DeMoe JH, et al. A high throughput, whole cell screen for small molecule inhibitors of the mitotic spindle checkpoint identifies OM137, a novel Aurora kinase inhibitor. Cancer Res. 2009 Feb 15;69(4):1509-16. DOI:10.1158/0008-5472.CAN-08-3133
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