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ChemicalBook--->CAS DataBase List--->289905-88-0

289905-88-0

289905-88-0 Structure

289905-88-0 Structure
IdentificationBack Directory
[Name]

TRAM-34
[CAS]

289905-88-0
[Synonyms]

Triarylmethane-34
[Molecular Formula]

C22H17ClN2
[MDL Number]

MFCD06798354
[MOL File]

289905-88-0.mol
[Molecular Weight]

344.843
Chemical PropertiesBack Directory
[Appearance]

Yellow Solid
[Melting point ]

145-147°C
[storage temp. ]

2-8°C
[solubility ]

DMSO: ~11 mg/mL
[form ]

solid
[color ]

off-white
[Water Solubility ]

Soluble in DMSO at 2mg/ml. Insoluble in water
[CAS DataBase Reference]

289905-88-0
Hazard InformationBack Directory
[Chemical Properties]

Yellow Solid
[Uses]

TRAM-34 blocks intermediate conductance calcium-activated potassium channel IKCa1 with a Kd of 20nM and exhibits exquisite selectivity for the channel. Clotrimazole impurity.
[Biological Activity]

Highly selective blocker of intermediate conductance Ca 2+ -activated K + channels (IK Ca 1, K Ca 3.1) (K d = 20 nM). Exhibits 200-1500-fold selectivity over K V , BK Ca , SK Ca , Na + , CRAC and Cl - channels. Suppresses the reactivation of lymphocytes by mitogenic stimuli.
[Definition]

ChEBI: TRAM-34 is an organochlorine compound.
[Biochem/physiol Actions]

TRAM-34 exhibits 100-fold selectivity (Kd = 20 nM) for IKCa1 channels over other K+ channels (Charybdotoxin, Kd = 5 nM, Clotrimazole, Kd = 70 nM; Nitrendipine Kd = 900 nM). Furthermore, TRAM-34 is known to suppress the activation of human T lymphocytes,.
[storage]

Store at -20°C
Safety DataBack Directory
[Hazard Codes ]

Xn
[Risk Statements ]

22
[WGK Germany ]

3
Spectrum DetailBack Directory
[Spectrum Detail]

TRAM-34(289905-88-0)1HNMR
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