| Identification | Back Directory | [Name]
NPS 2143 | [CAS]
284035-33-2 | [Synonyms]
CS-276
CS-1600
NPS 2143
SB262470
SB 262470A
NPS-2143 base
NPS 2143 USP/EP/BP
SB-262470(NPS-2143)
NPS-2143 (SB-262470)
NPS-2143(SB 262470A )
2-chloro-6-[(2R)-3-[[1
NPS 2143 hydrochloride
NPS 2143; SB 262470A ; NPS2143
NPS 2143, SB262470 hydrochloride
NPS 2143 hydrochloride(SB-262470)
NPS 2143;SB 262470A;NPS2143;SB262470
NPS-2143;NPS 2143; SB 262470A; NPS2143
1-diMethyl-2-(2-naphthalenyl)ethyl]aMino]-2-hydroxypropoxy]-
2-Chloro-6-[3-[1, 1-diMethyl-2-(2-naphthyl)ethylaMino]-2(R)-hydroxypropoxy]benzonitrile
2-Chloro-6-[3-[1, 1-dimethyl-2-(2-naphthyl)ethylamino]-2(R)-hydroxypropoxy]benzonitrile(NPS 2
2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile
(R)-2-chloro-6-(2-hydroxy-3-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)propoxy)benzonitrile
2-Chloro-6-[(2R)-2-hydroxy-3-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]propoxy]benzonitrile
2-Chloro-6-[3-[1, 1-dimethyl-2-(2-naphthyl)ethylamino]-2(R)-hydroxypropoxy]benzonitrile(NPS 2143)
Benzonitrile, 2-chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]- | [Molecular Formula]
C24H25ClN2O2 | [MDL Number]
MFCD04113010 | [MOL File]
284035-33-2.mol | [Molecular Weight]
408.92 |
| Chemical Properties | Back Directory | [Boiling point ]
608.4±55.0 °C(Predicted) | [density ]
1.23±0.1 g/cm3(Predicted) | [storage temp. ]
Desiccate at RT | [solubility ]
≥40.9 mg/mL in DMSO; insoluble in H2O; ≥28.35 mg/mL in EtOH | [form ]
Powder | [pka]
13.67±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
NPS 2143 acts as a potent and selective antagonist for CaSR (Calcium-sensing receptor) which is involved in calcium blood concentration homeostasis. | [Biological Activity]
nps-2143 is a novel and selective antagonist of casr (ca2+-sensing receptor) with the ec50 value of 4.27mm for [ca2+]o [1].calcilytics nps-2143 has been reported to diminish the sensitivity of the casr for [ca2+]o, resulting in an attenuated signal transduction in vitro and increased secretion of pth in vivo. in addition, the ec50 values of nps-2143 are 4.27, 1.56, 1.61, 2.46, 2.07 and 3.15mm for the wild-type casr, mutant casr (t151r, p221l, e767q, g830s, and a844t), respectively. apart from these, in hek 293t cells expressing casr, nps-2143 has been revealed to inhibit the [ca2+]o-induced cytosolic calcium signal in a concentration-dependent manner [1].. | [in vivo]
NPS-2143 (SB-262470A) results in a rapid 4- to 5-fold increase in plasma PTH levels in rats[1].
In normotensive rats, NPS-2143 administration (1 mg/kg, i.v.) markedly increases mean arterial blood pressure (MAP) in the presence of parathyroid glands[2]. | [target]
Ca(2+) receptor | [storage]
Store at -20°C | [References]
[1] letz s1, rus r, haag c, d?rr hg, schnabel d, m?hlig m, schulze e, frank-raue k, raue f, mayr b, sch?fl c. novel activating mutations of the calcium-sensing receptor: the calcilytic nps-2143 mitigates excessive signal transduction of mutant receptors. j clin endocrinol metab. 2010 oct;95(10):e229-33. |
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