| Identification | Back Directory | [Name]
Pyrazolo[1,5-a]pyridine | [CAS]
274-56-6 | [Synonyms]
3-Azaindoline
PYRAZOLO[1,5-A]PYRIDINE
1H-Pyrazolo[1,5-a]pyridine
Pyrazolo[1,5-a]pyridine,97%
6,7a-dimethyl-2,3,5,6-tetrahydrooxazolo[2,3-b]oxazole | [Molecular Formula]
C7H6N2 | [MDL Number]
MFCD08752622 | [MOL File]
274-56-6.mol | [Molecular Weight]
118.14 |
| Chemical Properties | Back Directory | [Boiling point ]
37-39℃/0.2mm | [density ]
1.14±0.1 g/cm3(Predicted) | [refractive index ]
1.6075 | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
Liquid | [pka]
2.83±0.30(Predicted) | [color ]
Colorless to red or brown |
| Hazard Information | Back Directory | [Description]
Pyrazolo[1,5-a]pyridines, a class of fused heteroaromatic bicyclic compounds, have been investigated for their pharmacological and biological activities. They are used as dopamine D2/D3/D4 antagonists, anti-herpetic agents, p38 kinase inhibitors, PI3 kinase inhibitors, antitubercular agents, EP1 receptor antagonists, 5HT3-antagonists, melatonin receptor (MT1/MT2) ligands, Mcl-1Bcl-xL dual inhibitors, and corticotropin-releasing factor 1 antagonists. Pyrazolo[1,5-a]pyridine has been used as a fluorophore in the research of Zhang et al. and exhibited high quantum yield (0.64, pH 2.4), high selectivity and sensitivity, and extremely short response time[1].
| [References]
[1] Brian A Johns. “Pyrazolo[1,5-a]pyridines: synthetic approaches to a novel class of antiherpetics.” Tetrahedron 59 45 (2003): Pages 9001-9011.
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