| Identification | Back Directory | [Name]
4-formylcolchicine | [CAS]
2730-82-7 | [Synonyms]
4-formylcolchicine
Acetamide, N-[(7S)-4-formyl-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]- | [Molecular Formula]
C23H25NO7 | [MOL File]
2730-82-7.mol | [Molecular Weight]
427.45 |
| Hazard Information | Back Directory | [Uses]
4-Formylcolchicine is a potent anticancer agent. 4-Formylcolchicine shows cytotoxicity activity with IC50 values of 1.007, 0.128, 0.054 μM for A549, HT-29, HCT116 cells, respectively[1][2]. | [References]
[1] Formylcolchicine bound to lactosaminated serum albumin is a more active antifibrotic agent than free colchicine
[2] Yasobu N, et al. Design, Synthesis, and Antitumor Activity of 4-Halocolchicines and Their Pro-drugs Activated by Cathepsin B. ACS Med Chem Lett. 2011 Mar 4;2(5):348-52. |
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