| Chemical Properties | Back Directory | [Boiling point ]
643.369±55.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.503±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
12.120±0.70(predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
URAT1&XO inhibitor 1 (compound 29) is a dual inhibitor of both URAT1 (IC50=~10 μM) and Xanthine Oxidase (IC50=1.01 μM). URAT1&XO inhibitor 1 results hypouricemic effect in potassium oxonate-induced hyperuricemia rat model. URAT1&XO inhibitor 1 is used for hyperuricemia research[1]. | [References]
[1] Fengwei Lin, et al. Identification of 5-[5-cyano-1-(pyridin-2-ylmethyl)-1H-indole-3-carboxamido] thiazole-4-carboxylic acid as a promising dual inhibitor of urate transporter 1 and xanthine oxidase. European Journal of Medicinal Chemistry. Volume 257, 5 September 2023, 115532. |
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