| Identification | Back Directory | [Name]
Colestipol HCl | [CAS]
26658-42-4 | [Synonyms]
tetraethylenepentamine/ epichlorohydrin copolymer
1,2-Ethanediamine, N-(2-aminoethyl)-N'-[2-[( 2-aminoethyl)amino]ethyl]-, polymer with (chloromethyl)oxirane | [Molecular Formula]
C11H28ClN5O | [MOL File]
26658-42-4.mol | [Molecular Weight]
281.83 |
| Hazard Information | Back Directory | [Originator]
Colestid,Upjohn,US,1977 | [Uses]
Antihyperlipidemic. | [Manufacturing Process]
Into a 1,000 gallon, jacketed, glass-lined reactor equipped with baffles and a
two-speed (67 and 135 rpm) reversed impeller is introduced 200 g of
Richonate 60B (a 60% aqueous slurry of sodium salts of alkylbenzenesulfonic
acids) and 364 liters of deionized water, followed by 90.5 kg of
tetraethylenepentamine rinsed in with 5 gallons of toluene. The solution is
stirred at the low speed and then 500 gallons of toluene are added to form a
dispersion. To the stirred dispersion is added 109 kg of epichlorohydrin, rinsed
in with 5 gallons of toluene, and the resulting mixture is heated at reflux for
two hours. The reaction mixture is cooled to about 20°C and then treated with
58.5 kg of a filtered 50% aqueous solution of sodium hydroxide. The mixture
is removed from the reactor and filtered, and the copolymer is collected and
dried by treating it first with hot (75°C to 80°C) filtered nitrogen and then
with an 80°C air stream. The resulting crude product is returned to the
reactor, washed extensively with filtered deionized water (at the low speed),
dried with an 80°C air stream and blended until homogeneous to give about
155 kg of a dry tetraethylenepentamine-epichlorohydrin copolymer
hydrochloride, particle diameter 0.002-0.02 inch. | [Brand name]
Colestid (Pharmacia & Upjohn). | [Therapeutic Function]
Antihyperlipoproteinemic |
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Pharma Affiliates
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172-5066494 |
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http://m.approvedhomemanagement.com/ShowSupplierProductsList694812/0.htm |
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