| Identification | Back Directory | [Name]
Urea, N-(3,4-dihydro-8-hydroxy-1,1-dioxido-2H-1-benzothiopyran-7-yl)-N'-(3-fluoro-2-methylphenyl)- | [CAS]
2647464-91-1 | [Synonyms]
CXCR2 antagonist 2
Urea, N-(3,4-dihydro-8-hydroxy-1,1-dioxido-2H-1-benzothiopyran-7-yl)-N'-(3-fluoro-2-methylphenyl)- | [Molecular Formula]
C17H17FN2O4S | [MOL File]
2647464-91-1.mol | [Molecular Weight]
364.39 |
| Chemical Properties | Back Directory | [Boiling point ]
473.4±45.0 °C(Predicted) | [density ]
1.504±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, away from moisture and light | [form ]
Solid | [pka]
6.68±0.20(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Description]
CXCR2 antagonist 2 is a potent CXCR2 antagonist for cancer immunotherapy with an IC50 value of 95 nM. | [Uses]
CXCR2 antagonist 2 is a potent CXCR2 antagonist for cancer immunoresearch with an IC50 value of 95 nM. | [References]
[1] Dong Y, et al. Discovery of Benzocyclic Sulfone Derivatives as Potent CXCR2 Antagonists for Cancer Immunotherapy. J Med Chem. 2021 Nov 25;64(22):16626-16640. DOI:10.1021/acs.jmedchem.1c01219 |
|
|