Identification | Back Directory | [Name]
Benzamide, 3-(5-methyl-1,2,4-oxadiazol-3-yl)-N-[trans-4-[2-[1,2,4,5-tetrahydro-7-(methylsulfonyl)-3H-3-benzazepin-3-yl]ethyl]cyclohexyl]- | [CAS]
264262-71-7 | [Synonyms]
SB414796 SB-414796 SB 414796 Benzamide, 3-(5-methyl-1,2,4-oxadiazol-3-yl)-N-[trans-4-[2-[1,2,4,5-tetrahydro-7-(methylsulfonyl)-3H-3-benzazepin-3-yl]ethyl]cyclohexyl]- | [Molecular Formula]
C29H36N4O4S | [MOL File]
264262-71-7.mol | [Molecular Weight]
536.69 |
Hazard Information | Back Directory | [Description]
SB-414796 is a potent and selective dopamine D3 receptor antagonist. | [Uses]
SB-414796 is a selective, orally active and cross the blood-brain barrier dopamine D3 receptor antagonist with Ki values of 4, 400 nM for D3, D2, respectively[1][2]. | [IC 50]
D3 Receptor: 4 nM (Ki); D2 Receptor: 400 nM (Ki) | [References]
[1] Macdonald GJ, et al. Design and synthesis of trans-3-(2-(4-((3-(3-(5-methyl-1,2,4-oxadiazolyl))- phenyl)carboxamido)cyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine (SB-414796): a potent and selective dopamine D3 receptor antagonist. J Med Chem. 2003 Nov 6;46(23):4952-64. DOI:10.1021/jm030817d [2] Heidbreder CA, et al. Current perspectives on selective dopamine D(3) receptor antagonists as pharmacotherapeutics for addictions and related disorders. Ann N Y Acad Sci. 2010 Feb;1187:4-34. DOI:10.1111/j.1749-6632.2009.05149.x |
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