| Identification | Back Directory | [Name]
PPT | [CAS]
263717-53-9 | [Synonyms]
PPT
-triyl)trisphenol
Propylpyrazole Triol
1,3,5-TRIS(4-HYDROXYPHENYL)-4-PROPYL-1H-PYRAZOLE
4,4',4''-(4-Propyl-[1H]-pyrazole-1,3,5
4,4',4''-(4-PROPYL-[1H]-PYRAZOLE-1,3,5-TRIYL)TRISPHENOL
Phenol, 4,4',4''-(4-propyl-1H-pyrazole-1,3,5-triyl)tris- | [Molecular Formula]
C24H22N2O3 | [MDL Number]
MFCD03453628 | [MOL File]
263717-53-9.mol | [Molecular Weight]
386.44 |
| Chemical Properties | Back Directory | [Melting point ]
230 °C (decomp) | [Boiling point ]
630.0±55.0 °C(Predicted) | [density ]
1.24±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 20 mg/mL, soluble
| [form ]
solid
| [pka]
8.80±0.15(Predicted) | [color ]
off-white
|
| Hazard Information | Back Directory | [Uses]
PPT is a potent and specific ERα agonist. | [Definition]
ChEBI: 4,4',4''-(4-propylpyrazole-1,3,5-triyl)trisphenol is a pyrazole that is 1H-pyrazole bearing three 4-hydroxyphenyl substituents at positions 1, 3 and 5 as well as a propyl substituent at position 4. Potent, subtype-selective estrogen receptor agonist (EC50 ~ 200 pM); displays 410-fold selectivity for ERalpha over ERbeta. Prevents ovariectomy-induced weight gain and loss of bone mineral density, and induces gene expression in the hypothalamus following systemic administration in vivo. It has a role as an estrogen receptor agonist. It is a member of pyrazoles and a member of phenols. | [General Description]
Estrogen receptor α (ERα) is a member of the nuclear receptor superfamily. It is also known as ESR1 (estrogen receptor). It is located on human chromosome 6q25.1.
1,3,5-tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole is also termed as PPT. ERα is found in the nuclear and extranuclear sites in principal and inhibitory neurons. | [Biological Activity]
Potent, subtype-selective estrogen receptor agonist (EC 50 ~ 200 pM); displays 410-fold selectivity for ER α over ER β . Prevents ovariectomy-induced weight gain and loss of bone mineral density, and induces gene expression in the hypothalamus following systemic administration in vivo . | [Biochem/physiol Actions]
Estrogen receptor α (ERα) is involved in immune and inflammatory responses. Aberrations in ESR1 results in Mayer-Rokitansky-Kuster-Hauser syndrome that is associated with the congenital absence of the uterus and the upper two-thirds of the vagina. | [storage]
+4°C |
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