| Identification | Back Directory | [Name]
ZPCK | [CAS]
26049-94-5 | [Synonyms]
ZPCK
SL-01
Z-PHE-CMK
NSC 251810
Z-L-Phe-CMK
Z-PHE-CH2CL
Z-L-Phe-Chloromethane
Z-PHE-CHLOROMETHYLKETONE
z-l-phe chloromethyl ketone
Z-L-Phe chloromethyl ketone 98%
Z-L-PHENYLALANINE-CHLOROMETHYLKETONE
N-CBZ-L-PHENYLETHYL CHLOROMETHYL KETONE
N-CBZ-L-PHENYLALANYL-CHLOROMETHYLKETONE
N-CBZ-L-PHENYLALANINE CHLOROMETHYL*KETON E
(S)-(1-benzyl-3-chloro-2-oxopropyl)carbamic
(S)-benzyl [1-benzyl-3-chloro-2-oxopropyl]carbamate
N-CARBOBENZYLOXY-L-PHENYLALANYL CHLOROMETHYL KETONE
(S)-Penzyl [1-benzyl-3-chloro-2-oxopropyl]carbamate.
N-Carbobenzyloxy-L-phenylalanyl chloromethylketone,98%
N-ALPHA-CARBOBENZOXY-L-PHENYLALANINE CHLOROMETHYLKETONE
(S)-Benzyl (4-chloro-3-oxo-1-phenylbutan-2-yl)carbamate
[(S)-α-(Chloroacetyl)phenethyl]carbamic acid benzyl ester
ZPCK, N-Carbobenzyloxy-L-phenylalanyl chloromethyl ketone
(3S)-1-Chloro-3-(benzyloxycarbonylamino)-4-phenyl-2-butanone
[(S)-1-Benzyl-3-chloro-2-oxopropyl]carbamic acid benzyl ester
carbamicacid,[3-chloro-2-oxo-1-(phenylmethyl)propyl]-,phenylmethylester,(s
N-Carbobenzyloxy-L-phenylalanyl chloromethyl ketoneN-CBZ-L-Phenylalanylchloromethyl ketone | [EINECS(EC#)]
247-432-8 | [Molecular Formula]
C18H18ClNO3 | [MDL Number]
MFCD00037114 | [MOL File]
26049-94-5.mol | [Molecular Weight]
331.79 |
| Chemical Properties | Back Directory | [Appearance]
white powder | [Melting point ]
107-108 °C(lit.)
| [Boiling point ]
503.1±50.0 °C(Predicted) | [density ]
1.1630 (rough estimate) | [refractive index ]
1.6470 (estimate) | [storage temp. ]
-15°C | [solubility ]
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 15 mg/ml with warming). | [form ]
solid | [pka]
10.74±0.46(Predicted) | [color ]
White | [optical activity]
[α]23/D +30°, c = 1 in chloroform | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. | [CAS DataBase Reference]
26049-94-5 | [EPA Substance Registry System]
Benzyl [(1S)-3-chloro-2-oxo-1-benzylpropyl]carbamate (26049-94-5) |
| Hazard Information | Back Directory | [Chemical Properties]
white powder | [Uses]
It peptidase and esterase activities of carboxypeptidase Y from baker's yeast. | [Uses]
SL 01 is a prodrug of gemcitabine , the nucleoside analog used intravenously to treat various cancers that was designed for improved oral bioavailability. SL 01 can inhibit the growth of human non-small cell lung cancer NCI-H460 cells, colon cancer HCT-116 cells, and breast cancer MCF-7 cells (IC50s = 0.78, 0.92, and 0.64 μM, respectively), inducing apoptosis. In nude mice bearing NCI-H460, HCT-116, or MCF-7 cancer cell xenografts, SL 01 at 10-50 μM/kg has been shown to delay tumor growth. | [Description]
SL-01 (26049-94-5) inhibits the p53-MDM2 interaction (20 μM). Has also been shown to inhibit bovine chymotrypsin A-γ. | [reaction suitability]
reaction type: solution phase peptide synthesis | [storage]
Store at -20°C | [References]
1) Li et al. (2011), A cell-based high-throughput assay for the screening of small-molecule inhibitors of p53-MDM2 interaction; J. Biomol. Screening, 16 450 |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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