| Identification | Back Directory | [Name]
GI 254023X | [CAS]
260264-93-5 | [Synonyms]
GI4023
GI 254023X
SRI 028594)
GI 254023X(GI 4023
GI 254023X;GI-254023X;GI4023;SRI028594
GI254023X; GI 254023X; GI-254023X;GI4023; GI-4023; GI 4023
(2R)-N-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl]propyl]-2-[(1S)-1-(N-hydroxyformamido)ethyl]-5-phenylpentanamide
(2R)-N-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl]-propyl]-2-[(1S)-1-[formyl(hydroxy)amino]ethyl]-5-phenylpentanamide
Benzenepentanamide, N-[(1S)-2,2-dimethyl-1-[(methylamino)carbonyl]propyl]-α-[(1S)-1-(formylhydroxyamino)ethyl]-, (αR)-
((2R,3S)-3-(formyl-hydroxyamino)-2-(3-phenyl-1-propyl)butanoic acid [(1S)-2,2-dimethyl-1-methylcarbamoyl-1-propyl] amide)
(alphaR)-N-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl]propyl]-alpha-[(1S)-1-(formylhydroxyamino)ethyl]benzenepentanamide | [Molecular Formula]
C21H33N3O4 | [MDL Number]
MFCD19381832 | [MOL File]
260264-93-5.mol | [Molecular Weight]
391.51 |
| Chemical Properties | Back Directory | [density ]
1.112±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble15mg/mL, clear | [form ]
powder | [pka]
8.48±0.69(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
GI 254023X is an ADAM10 metaloproteinase inhibitor. | [Uses]
GI254023X has been used to inhibit ADAM10 (ADAM metallopeptidase domain 10). | [Definition]
ChEBI: GI254023X is a L-valine derivative that is 3-methyl-L-valine in which carboxy OH group is replaced by a methylnitrilo group and the one of the amino hydrogens is replaced by a (2R)-2-{(1S)-1-[formyl(hydroxy)amino]ethyl}-5-phenylpentanoyl group. It is a potent MMP9 and ADAM10 metalloprotease inhibitor with IC50 of 2.5 and 5.3 nM, respectively. It has a role as an apoptosis inducer, an antineoplastic agent, a matrix metalloproteinase inhibitor and an EC 3.4.24.* (metalloendopeptidase) inhibitor. It is a L-valine derivative, an aldehyde and a member of hydroxylamines. | [Biochem/physiol Actions]
GI254023X is a potent and selective ADAM10 metalloproteinase inhibitor. | [storage]
Store at -20°C |
|
|