| Identification | Back Directory | [Name]
N-(1-Phenylcyclohexyl)-1,5-pentanediamine dihydrobromide | [CAS]
258282-23-4 | [Synonyms]
IEM 1925 DIHYDROBROMIDE
N-(1-Phenylcyclohexyl)-1,5-pentanediamine dihydrobromide
N'-(1-phenylcyclohexyl)pentane-1,5-diamine dihydrobromide | [Molecular Formula]
C17H28N2.2HBr | [MDL Number]
MFCD19690950 | [MOL File]
258282-23-4.mol | [Molecular Weight]
422.24 |
| Hazard Information | Back Directory | [Uses]
IEM 1925 dihydrobromide is a use and voltage-dependent open-channel antagonist of AMPA receptors. | [in vivo]
IEM-1925 (10 mg/kg) weakens the behavioral motor convulsive signs of SE in rats, decreasing seizure intensity from 8 to 4 points on the Pinel and Rovner scale[2].
| Animal Model: | Rats (males, weight 240-350 g)[2].
| | Dosage: | 5, 10 mg/kg. | | Administration: | i.m. | | Result: | Administration of 5 and 10 mg/kg IEM-1925 2 h before pilocarpine did not alter the overall SE pattern. However, IEM-1925 significantly changed the latent periods of onset and durations of the separate phases and also decreased the total duration of status. |
| [storage]
Desiccate at RT |
|
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