| Identification | Back Directory | [Name]
AM1172 | [CAS]
251908-92-6 | [Synonyms]
AM1172
N-5Z,8Z,11Z,14Z-EICOSATETRAENYL-4-HYDROXY-BENZAMIDE
4-hydroxy-N-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenyl]benzamide
N-(5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraen-1-yl-4-hydroxybenzamide
Benzamide, N-(5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraen-1-yl-4-hydroxy- | [Molecular Formula]
C27H39NO2 | [MDL Number]
MFCD08062148 | [MOL File]
251908-92-6.mol | [Molecular Weight]
409.6 |
| Chemical Properties | Back Directory | [Boiling point ]
590.8±50.0 °C(Predicted) | [density ]
0.983±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in ethanol | [form ]
solution in ethanol | [pka]
8.53±0.26(Predicted) |
| Hazard Information | Back Directory | [Uses]
AM 1172 is a potent and selective inhibitor of anandamide uptake and FAAH. | [Biological Activity]
Metabolically stable anandamide uptake inhibitor (IC 50 = 2.1 - 2.5 μ M) and fatty acid amide hydrolase (FAAH) inhibitor (K i = 3.18 μ M). Inhibits N -arachidonylethanolamine (AEA) accumulation (IC 50 = 24 μ M) and hydrolysis (K i = 3 μ M), and inhibits N -palmitoylethanolamine (PEA) hydrolysis (IC 50 = 36 μ M) in cerebellar granule neurons. Also acts as a non-selective cannabinoid receptor partial agonist (EC 50 values are 189 and 271 nM at CB 2 and CB 1 receptors respectively). | [References]
1. fegley d, kathuria s, mercier r, et al. anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor am1172. proceedings of the national academy of sciences of the united states of america. 2004;101(23):8756-8761. |
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