| Identification | Back Directory | [Name]
(PHE1,SER2,TYR6)-PAR-1 (1-6) AMIDE (HUMAN) | [CAS]
245329-02-6 | [Synonyms]
FSLLRY-NH2
FSLLRY-amide
PHE-SER-LEU-LEU-ARG-TYR- NH2
H-PHE-SER-LEU-LEU-ARG-TYR-NH2
FSLLRY-NH2 trifluoroacetate salt
(PHE1,SER2,TYR6)-PAR-1 (1-6) AMIDE (HUMAN)
L-Phenylalanyl-L-seryl-L-leucyl-L-leucyl-L-arginyl-L-tyrosinaMide
L-Tyrosinamide, L-phenylalanyl-L-seryl-L-leucyl-L-leucyl-L-arginyl-
FSLLRYaMide, (Phe1,Ser2,Tyr6)-Coagulation Factor II Receptor (1-6) aMide (Mouse), (Phe1,Ser2,Tyr6)-Proteinase Activated Receptor 1 (1-6) aMide (huMan), (Phe1,Ser2,Tyr6)-ThroMbin Receptor (1-6) aMide (huMan) | [Molecular Formula]
C39H60N10O8 | [MDL Number]
MFCD08458636 | [MOL File]
245329-02-6.mol | [Molecular Weight]
796.96 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
Acetonitrile: 0.5 mg/ml; DMSO: 20 mg/ml | [form ]
powder | [color ]
white to off-white | [Water Solubility ]
Soluble to 1 mg/ml in water |
| Hazard Information | Back Directory | [Uses]
L-Phenylalanyl-L-seryl-L-leucyl-L-leucyl-L-arginyl-L-tyrosinamide, is a peptide agonist of proteinase-activated receptor1,and 2 (PAR-1 and -2), and thus can be used to study PAR1,2 action in cells and in animals. | [Biological Activity]
FSLLRY-NH2 is a peptide antagonist of the protease activated receptor 2 (PAR2). The peptide blocks agonist induced itching in rodent models. In cell based assaysthe peptide inhibits agonist-induced cardiocyte remodelingand production of cytokines by endothelial cells.''The ability of FSLLRY-NH2 to decrease visceral hypersensitivity (VH) suggests th at PAR2 is involved in the maintenance of VH. | [storage]
-20°C |
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