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ChemicalBook--->CAS DataBase List--->2448414-48-8

2448414-48-8

2448414-48-8 Structure

2448414-48-8 Structure
IdentificationBack Directory
[Name]

BRD7 inhibitor 1
[CAS]

2448414-48-8
[Synonyms]

BRD7 inhibitor 1
[Molecular Formula]

C22H27ClN4O3
[MDL Number]

MFCD32062734
[MOL File]

2448414-48-8.mol
[Molecular Weight]

430.93
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Solid
[color ]

Off-white to yellow
Hazard InformationBack Directory
[Uses]

BRD7-IN-1, a modified derivative of BI7273 (BRD7/9 inhibitor), binds to a VHL ligand via a linker to form a PROTAC VZ185 (VZ185 against BRD7/9 with DC50s of 4.5 and 1.8 nM, respectively)[1].
[storage]

Store at -20°C
[References]

[1] Zoppi V, et al. Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel-Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7. J Med Chem. 2019 Jan 24;62(2):699-726. DOI:10.1021/acs.jmedchem.8b01413
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