| Identification | Back Directory | [Name]
2(1H)-Pyridinone, 4-[(2,6-dichlorophenyl)thio]-3-[(1,3-dihydro-5,6-dimethoxy-2H-isoindol-2-yl)carbonyl]-6-(trifluoromethyl)- | [CAS]
2438637-61-5 | [Synonyms]
2(1H)-Pyridinone, 4-[(2,6-dichlorophenyl)thio]-3-[(1,3-dihydro-5,6-dimethoxy-2H-isoindol-2-yl)carbonyl]-6-(trifluoromethyl)- | [Molecular Formula]
C23H17Cl2F3N2O4S | [MDL Number]
MFCD32062681 | [MOL File]
2438637-61-5.mol | [Molecular Weight]
545.36 |
| Chemical Properties | Back Directory | [Boiling point ]
628.7±55.0 °C(Predicted) | [density ]
1.57±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 8.33 mg/mL (15.27 mM; Need ultrasonic) | [form ]
Solid | [pka]
5.43±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation, with an EC50 of 3.8 nM[1]. | [References]
[1] Kyle R. Simonetta, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nature Communications. 2019 March. |
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www.jiehuapharma.com/ |
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