| Identification | Back Directory | [Name]
Piperidine, 1-(2-phenoxyethyl)-4-(phenylmethyl)-, hydrochloride (1:1) | [CAS]
242487-82-7 | [Synonyms]
S1R agonist 1 hydrochloride | [Molecular Formula]
C20H25NO.ClH | [MOL File]
242487-82-7.mol | [Molecular Weight]
331.88 |
| Hazard Information | Back Directory | [Uses]
S1R agonist 1 (Compound 6b) hydrochloride is a selective S1R agonist with Kis of 0.93 nM and 72 nM for S1R and S2R, respectively. S1R agonist 1 hydrochloride exhibits neuroprotection against ROS and NMDA-induced neurotoxicity[1]. | [in vivo]
S1R agonist 1 (Compound 6b; 0.1-50 μM; 120 h) hydrochloride induces the death of 4 Zebrafish embryos out of 8 at 10 μM[1]. | [References]
[1] Linciano P, et al. Novel S1R agonists counteracting NMDA excitotoxicity and oxidative stress: A step forward in the discovery of neuroprotective agents. Eur J Med Chem. 2023 Mar 5;249:115163. DOI:10.1016/j.ejmech.2023.115163 |
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Biorbyt Ltd.
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