Chemical Properties | Back Directory | [Boiling point ]
377.3±42.0 °C(Predicted) | [density ]
1.10±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
13.55±0.70(Predicted) | [color ]
White to off-white |
Hazard Information | Back Directory | [Uses]
MAO-B-IN-9 (compound 16) is a potent, selective, BBB-penetrated, irreversible and time-dependent MAO-B (monoamine oxidase B) inhibitor, with an IC50 of 0.18 μM. MAO-B-IN-9 prevents Aβ1-42-induced neuronal cell death. MAO-B-IN-9 shows neuroprotective effects, which may be the result of its Aβ1-42 anti-aggregation effects[1]. MAO-B-IN-9 is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
MAO-B: 0.178 ± 0. μM (IC50) | [References]
[1] Ko?ak U, et al. N-alkylpiperidine carbamates as potential anti-Alzheimer's agents. Eur J Med Chem. 2020 Jul 1;197:112282. DOI:10.1016/j.ejmech.2020.112282 |
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