| Chemical Properties | Back Directory | [Boiling point ]
421.7±45.0 °C(Predicted) | [density ]
1.245±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 250 mg/mL (838.08 mM; Need ultrasonic) | [form ]
Solid | [pka]
5.17±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
MYF-01-37 is a covalent TEAD inhibitor targeting Cys380. MYF-01-37 has a reversible inhibition on YAP/TEAD interaction[1]. | [IC 50]
YAP/TAZ-TEAD | [References]
[1] Kari J Kurppa, et al. Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway. Cancer Cell. 2020 Jan 13;37(1):104-122.e12. DOI:10.1016/j.ccell.2019.12.006 |
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