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Ulenistamab (PBP1510) is a first-in-class hunamised IgG1 monoclonal antibody targeting pancreatic adenocarcinoma upregulated factor (PAUF). Ulenistamab can be used for pancreatic cancer (PC) research[1]. | [in vivo]
Pharmacokinetic (PK) characteristics and immunogenicity of PBP1510 (up to 20 mg/kg), are examined in single dose studies in 6 monkeys. In monkey studies, a dose-proportional increase in systemic exposure was observed at low and high doses[1]. | [References]
[1] Kedar Diwakar Mandakhalikar, et al. First-in-class monoclonal antibody (mAb) PBP1510 targeting pancreatic adenocarcinoma upregulated factor (PAUF) for pancreatic cancer (PC) treatment: Preclinical perspectives. Journal of Clinical Oncology 2022 40:16_suppl, e16274-e16274. |
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