| Identification | Back Directory | [Name]
6'-GNTI dihydrochloride | [CAS]
2410327-94-3 | [Synonyms]
6'-GNTI dihydrochloride
6'-GNTI dihydrochloride | [Molecular Formula]
C27H30ClN5O3 | [MDL Number]
MFCD06795850 | [MOL File]
2410327-94-3.mol | [Molecular Weight]
508.02 |
| Hazard Information | Back Directory | [Uses]
6'-GNTI dihydrochloride, a κ-opioid receptor (KOR) agonist, displays bias toward the activation of G protein-mediated signaling over β-arrestin2 recruitment. 6'-GNTI 6'-GNTI dihydrochloride only activates the Akt pathway in striatal neurons[1]. | [References]
[1] Schmid CL, et al. Functional selectivity of 6'-guanidinonaltrindole (6'-GNTI) at κ-opioid receptors in striatal neurons. J Biol Chem. 2013;288(31):22387-22398. DOI:10.1074/jbc.M113.476234 |
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