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ChemicalBook--->CAS DataBase List--->2409963-83-1

2409963-83-1

2409963-83-1 Structure

2409963-83-1 Structure
IdentificationBack Directory
[Name]

2-Buten-1-amine, 3-fluoro-4-(8-quinolinylsulfonyl)-, (2Z)-
[CAS]

2409963-83-1
[Synonyms]

PXS5505
DWN63831
LOX-IN-3
LOXIN3,LOX IN 3
Lysyl oxidase inhbitor 1
2-Buten-1-amine, 3-fluoro-4-(8-quinolinylsulfonyl)-, (2Z)-
[Molecular Formula]

C13H13FN2O2S
[MDL Number]

MFCD34167539
[MOL File]

2409963-83-1.mol
[Molecular Weight]

280.32
Chemical PropertiesBack Directory
[Boiling point ]

529.1±50.0 °C(Predicted)
[density ]

1.330±0.06 g/cm3(Predicted)
[storage temp. ]

4°C, protect from light
[solubility ]

DMSO : 125 mg/mL (445.92 mM; Need ultrasonic)
[form ]

Solid
[pka]

6.96±0.29(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

LOX-IN-3 is an orally active lysyl oxidase (LOX) inhibitor. LOX-IN-3 can be used for fibrosis, cancer and angiogenesis research[1].
[in vivo]

LOX-IN-3 dihydrochloride monohydrate (Compound 33) (30 mg/kg; orally; once) inhibits lysyl oxidase activity in rats[1].
LOX-IN-3 dihydrochloride monohydrate (10 mg/kg; orally; daily for 14 days) reduces kidney fibrosis in unilateral ureteric obstruction (UUO) mice model[1].
LOX-IN-3 dihydrochloride monohydrate (15 mg/kg; orally; daily for 21 days) reduces lung fibrosis in mice[1].

Animal Model:Male Wistar rats[1]
Dosage:30 mg/kg
Administration:Oral administration, single dose
Result:Completely abolished lysyl oxidase activity. Plasma concentrations of tested compound are far below the IC50 after 8 hours, the half-life of recovery is between 2-3 days (ear) and 24 hours (aorta).
Animal Model:Unilateral ureteric obstruction (UUO) model of acute kidney fibrosis in mice[1]
Dosage:10 mg/kg
Administration:Oral gavage, daily for 14 days
Result:Increased kidney weight and thickness and reduced the area of fibrosis.
Animal Model:C57Bl/6 mice, Bleomycin-induced lung fibrosis model
Dosage:15 mg/kg
Administration:Oral gavage, daily for 21 days
Result:Significantly reduced the Ashcroft score and the lung weight.
[References]

[1] Alison Dorothy Findlay, et al. Haloallylamine sulfone derivative inhibitors of lysyl oxidases and uses thereof. WO2020024017A1.
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