| Identification | Back Directory | [Name]
2,6-Piperidinedione, 3-[4-[[2-[(2,3-dihydro-1H-inden-5-yl)amino]-4-pyrimidinyl]amino]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]- | [CAS]
2407654-51-5 | [Synonyms]
ZXH-1-161
2,6-Piperidinedione, 3-[4-[[2-[(2,3-dihydro-1H-inden-5-yl)amino]-4-pyrimidinyl]amino]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]- | [Molecular Formula]
C26H24N6O3 | [MOL File]
2407654-51-5.mol | [Molecular Weight]
468.51 |
| Chemical Properties | Back Directory | [density ]
1.451±0.06 g/cm3(Predicted) | [solubility ]
DMSO : 250 mg/mL (533.61 mM; Need ultrasonic) | [form ]
Solid | [pka]
10.70±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
ZXH-1-161 is a potent cereblon (CRBN) modulator with an IC50 value of 39 nM in MM1.S wild type cells. ZXH-1-161 has selective degradation activity towards GSPT1. ZXH-1-161 can be used for researching multiple myeloma[1]. | [Biological Activity]
ZXH-1-161 is a potent cereblon (CRBN) modulator with an IC50 value of 39 nM in MM1.S wild type cells. ZXH-1-161 has selective degradation activity towards GSPT1. ZXH-1-161 can be used for researching multiple myeloma[1]. | [IC 50]
Cereblon | [References]
[1]. Powell CE, et al. Selective Degradation of GSPT1 by Cereblon Modulators Identified via a Focused Combinatorial Library. ACS Chem Biol. 2020 Oct 16;15(10):2722-2730. |
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