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ChemicalBook--->CAS DataBase List--->2390147-17-6

2390147-17-6

2390147-17-6 Structure

2390147-17-6 Structure
IdentificationBack Directory
[Name]

Ginisortamab
[CAS]

2390147-17-6
[Synonyms]

Ginisortamab
Research Grade Ginisortamab (DHA94801)
Chemical PropertiesBack Directory
[form ]

Liquid
[color ]

Colorless to light yellow
Hazard InformationBack Directory
[Uses]

Ginisortamab (UCB6114) is a fully human IgG4P antiGremlin-1 monoclonal antibody, with mean IC50 values of 8.2 nM and 9 nM against human and mouse gremlin-1, respectivly. Ginisortamab inhibits gremlin-1 antagonism of BMP signaling pathways. Ginisortamab has the potential for the research of gastrointestinal (GI) tumors[1][2][3].
[in vivo]

Ginisortamab binds to gremlin-1 and has antitumor activity in several mouse models, including GI cancers[3].

[References]

[1] Debashis Sarker, et al. A multi-modular phase I/II study of UCB6114, a first-in-class, fully human IgG4P anti-Gremlin-1 monoclonal antibody, as monotherapy and in combination with mFOLFOX6 or trifluridine/tipiracil, for patients with advanced gastrointestinal (GI) tumors. Meeting Abstract, 2022 ASCO Gastrointestinal Cancers Symposium.
[2] Davies GCG, et al. Discovery of ginisortamab, a potent and novel anti-gremlin-1 antibody in clinical development for the treatment of cancer. MAbs. 2023 Jan-Dec;15(1):2289681. DOI:10.1080/19420862.2023.2289681
[3] Debashis Sarker, et al. Abstract CT094: Phase I dose-escalation study evaluating the safety and tolerability of ginisortamab (UCB6114), a first-in-class anti-gremlin-1 monoclonal antibody (mAb), as monotherapy in advanced solid tumors. Cancer Res (2023) 83 (8_Supplement): CT094 .
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