| Chemical Properties | Back Directory | [Boiling point ]
962.7±65.0 °C(Predicted) | [density ]
1.275±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C, protect from light, stored under nitrogen | [solubility ]
Soluble to 1 mg/ml in DMSO | [form ]
Solid | [pka]
3.93±0.19(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
Ac-FLTD-CMK is a selective gasdermin D (GSDMD) clevage inhibitor (IC50 = 46.7 nM329 nM1.49 μMrespectivelyagainst GSDMD clevage by human caspase-1-5-4 in cell-free enzymatic assays) th at suppresses pyroptosis downstream of both canonical and noncanonical inflammasomesas well as reduces IL-1β release following activation of the NLRP3 inflammasome in macrophages (10 μM 4h post 200 ng/mL LPS and 0.5h before ATP or nigericin). Ac-FLTD-CMK selectively blocks GSDMD clevage by inflammatory caspases without affecting apoptotic caspases (caspase-3 IC50 >100 μM) or apoptosis. | [storage]
Store at -20°C |
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