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ChemicalBook--->CAS DataBase List--->2368182-63-0

2368182-63-0

2368182-63-0 Structure

2368182-63-0 Structure
IdentificationBack Directory
[Name]

2-Pyridinecarboxamide, N,N'-(2,2'-dimethyl[1,1'-biphenyl]-3,3'-diyl)bis[5-[[(2-hydroxyethyl)amino]methyl]-
[CAS]

2368182-63-0
[Synonyms]

ARB-272572
2-Pyridinecarboxamide, N,N'-(2,2'-dimethyl[1,1'-biphenyl]-3,3'-diyl)bis[5-[[(2-hydroxyethyl)amino]methyl]-
[Molecular Formula]

C32H36N6O4
[MOL File]

2368182-63-0.mol
[Molecular Weight]

568.67
Chemical PropertiesBack Directory
[Boiling point ]

710.5±60.0 °C(Predicted)
[density ]

1.284±0.06 g/cm3(Predicted)
[form ]

Solid
[pka]

11.45±0.70(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Description]

ARB-272572 is a novel potent PD-L1 inhibitor, inducing PD-L1 dimerization and internalization.
[Uses]

ARB-272572 is an oral effective small molecule PD-L1 inhibitor, with an IC50 value of 400 pM. ARB-272572 has research significance in tumors and chronic viral infections[1][2].
[in vivo]

ARB-272572 (10 mg/kg; oral; once daily; seven days) inhibits tumor growth in humanized colon cancer mice[1].

Animal Model:Humanized mouse model of colon cancer [1]
Dosage:10 mg/kg; daily; 7 days
Administration:Oral
Result:Reduced tumor volume, tumor regression, and the number of CD3+ T cells in peripheral blood increased, especially CD4+ T cells significantly increased, while the proportion of regulatory T cells decreased significantly.
[References]

[1] Park JJ, et al. Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1. Nat Commun. 2021 Feb 22;12(1):1222. DOI:10.1038/s41467-021-21410-1
[2] Zhijie Wang, et al. Reducing PD-L1 Expression by Degraders and Downregulators as a Novel Strategy to Target the PD-1/PD-L1 Pathway. J Med Chem. 2024 Apr 25;67(8):6027-6043. DOI:10.1021/acs.jmedchem.3c02143
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