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ChemicalBook--->CAS DataBase List--->2361988-77-2

2361988-77-2

2361988-77-2 Structure

2361988-77-2 Structure
IdentificationBack Directory
[Name]

cRIPGBM
[CAS]

2361988-77-2
[Synonyms]

cRIPGBM(chloride)
1-Benzyl-3-(4-fluorobenzyl)-2-methyl-4,9-dioxo-4,9- dihydro-1H-naphtho[2,3-d]imidazol-3-ium chloride
[Molecular Formula]

C26H20ClFN2O2
[MDL Number]

MFCD34596421
[MOL File]

2361988-77-2.mol
[Molecular Weight]

446.91
Chemical PropertiesBack Directory
[storage temp. ]

2-8°C
[solubility ]

DMSO: 2mg/mL, clear
[form ]

Solid
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Biological Activity]

cRIPGBM is an apoptosis inducer (GBM-1/-5/-39 EC50 = 63/95/290 nM; human neural progenitor cells (NPCs)/astrocytes/lung fibroblasts EC50 = 190/710/960 nM) th at binds receptor-interacting protein kinase 2 (RIPK2RIP2) and promotes the formation of a proapoptotic RIPK2/caspase-1 complex. Cell type-selective metabolic redox conversion of RIPGBM to cRIPGBM in glioblastoma multiforme (GBM) cancer stem cells (CSCs) form the basis of selective GBM CSCs apoptosis induction by RIPGBM over non-GBM cultures.
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