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ChemicalBook--->CAS DataBase List--->2349374-37-2

2349374-37-2

2349374-37-2 Structure

2349374-37-2 Structure
IdentificationBack Directory
[Name]

9c(i472)
[CAS]

2349374-37-2
[Synonyms]

9c(i472)
15-LOX-1 inhibitor 1
[Molecular Formula]

C22H21ClN2O4
[MOL File]

2349374-37-2.mol
[Molecular Weight]

412.87
Chemical PropertiesBack Directory
[Boiling point ]

683.5±55.0 °C(Predicted)
[density ]

1.305±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: soluble; Methanol: slightly soluble
[form ]

A crystalline solid
[pka]

13.41±0.30(Predicted)
[color ]

Off-white to light yellow
Hazard InformationBack Directory
[Description]

9c(i472) is an inhibitor of 15-lipoxygenase-1 (15-LO-1; IC50 = 0.19 μM).1 It decreases LPS- and IFN-γ-induced NF-?B activity in RAW-Blue? cells when used at concentrations of 0.2, 1, and 5 μM. 9c(i472) reduces LPS- and IFN-γ-induced increases in Nos2 expression and lipid peroxidation in RAW 264.7 cells when used at a concentration of 5 μM.
[Uses]

15-LOX-1 inhibitor 1 is a potent inhibitor of 15-LOX-1 (15-lipoxygenase-1) with an IC50 value of 0.19 μM. 15-LOX-1 inhibitor 1 protects macrophages from lipopolysaccharide-induced cytotoxicity. 15-LOX-1 inhibitor 1 inhibits NO formation and lipid peroxidation[1].
[IC 50]

15-LOX-1: 0.19 μM (IC50)
[storage]

Store at -20°C
[References]

1. Guo, H., Verhoek, I.C., Prins, G.G.H., et al. Novel 15-lipoxygenase-1 inhibitor protects macrophages from lipopolysaccharide-induced cytotoxicity J. Med. Chem. 62(9),4624-4637(2019).
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